To the Editor: The management of disseminated carcinoma of thecervix that is no longer amenable to control with surgery orradiation therapy has not improved significantly with the adventof modern chemotherapy. The one-year survival rate remains between10 percent and 15 percent.1 Studies have provided a rationalefor using dendritic cells as natural adjuvants for human immunotherapy.2,3,4
We describe a 52-year-old woman with multiple lung metastasessecondary to recurrent human papillomavirus type 18 (HPV-18)associatedadenocarcinoma of the uterine cervix. In 1997 she underwentexternal irradiation and intracavitary brachytherapy combinedwith weekly intravenous infusions of cisplatin and followedby . . . [Full Text of this Article]
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Bellone, S., El-Sahwi, K., Cocco, E., Casagrande, F., Cargnelutti, M., Palmieri, M., Bignotti, E., Romani, C., Silasi, D.-A., Azodi, M., Schwartz, P. E., Rutherford, T. J., Pecorelli, S., Santin, A. D.
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(2008). Human Papillomavirus Type 16 and 18 E7-Pulsed Dendritic Cell Vaccination of Stage IB or IIA Cervical Cancer Patients: a Phase I Escalating-Dose Trial. J. Virol.
82: 1968-1979
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(2007). Therapeutic Synergy of Human Papillomavirus E7 Subunit Vaccines plus Cisplatin in an Animal Tumor Model: Causal Involvement of Increased Sensitivity of Cisplatin-Treated Tumors to CTL-Mediated Killing in Therapeutic Synergy. Clin. Cancer Res.
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Pouniotis, D. S., Proudfoot, O., Bogdanoska, V., Apostolopoulos, V., Fifis, T., Plebanski, M.
(2004). Dendritic Cells Induce Immunity and Long-Lasting Protection against Blood-Stage Malaria despite an In Vitro Parasite-Induced Maturation Defect. Infect. Immun.
72: 5331-5339
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Davidson, E. J., Sehr, P., Faulkner, R. L., Parish, J. L., Gaston, K., Moore, R. A., Pawlita, M., Kitchener, H. C., Stern, P. L.
(2003). Human papillomavirus type 16 E2- and L1-specific serological and T-cell responses in women with vulval intraepithelial neoplasia. J. Gen. Virol.
84: 2089-2097
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