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Previous Volume 346:1829-1830 June 6, 2002 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the study by the Diabetes Prevention Program Research Group (Feb. 7 issue),¹ the protocol did not include a washout period after metformin therapy. Such an approach could have been used to determine whether the subjects' plasma glucose concentrations were maintained within the nondiabetic range in the absence of treatment, as recommended by the 1997 criteria of the American Diabetes Association.² Such a finding would be necessary in order to conclude that metformin prevents type 2 diabetes.

Yousef Y. Bo-abbas, M.D.
Amiri Hospital
Rumaithya 25559, Kuwait
yboabbas@hotmail.com

References

1. Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002;346:393-403. [Free Full Text]
2. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 1997;20:1183-1197. [ISI][Medline]

References

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