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Correspondence
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Volume 346:1832-1833 June 6, 2002 Number 23
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Uterine Sarcoma Associated with Tamoxifen Use

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To the Editor: Between 1978, when tamoxifen was first marketed in the United States, and April 2001, there were 43 cases, reported either to the Food and Drug Administration (FDA) or in the medical literature,1 of uterine sarcoma that developed in women in the United States who had been receiving tamoxifen (Nolvadex, AstraZeneca) for breast cancer; these included one woman with ductal carcinoma in situ and one with stage I breast cancer. In addition, uterine sarcoma was reported to have developed in 116 women in other countries after they had taken tamoxifen for breast cancer. Primary histologic findings were consistent . . . [Full Text of this Article]

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