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Previous Volume 346:1902-1905 June 13, 2002 Number 24 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The syndrome of congestive heart failure is responsible for substantial morbidity and mortality.¹ Patients with heart failure have shortness of breath and a limited capacity for exercise, have high rates of hospitalization and rehospitalization, and die prematurely. The primary mode of therapy for this syndrome is based on antagonism of neurohormonal pathways (notably, the sympathetic nervous system² and the renin–angiotensin–aldosterone axis^3,4) activated in the failing cardiovascular system. Drugs that antagonize these pathways decrease mortality and morbidity^2,3,4 and in some cases improve the underlying structural abnormalities of the heart, a process termed "reverse remodeling."⁵ On the basis of a large . . . [Full Text of this Article]

References

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