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Correspondence
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Volume 346:1916-1918 June 13, 2002 Number 24
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Case 26-2001: Scleroderma Renal Crisis and Polymyositis

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 by Korn, J. H.
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To the Editor: We believe that an important myositis-associated autoantibody, which could be of interest in the differential diagnosis, was overlooked by Drs. Korn and Mauiyyedi in their discussion of Case 26-2001 (Aug. 23 issue).1 Anti–PM-Scl, formerly known as anti-PM1, reacts against an antigen of at least 11 subunits, although the major antigen is the 100-kD protein. Almost all anti–PM-Scl autoantibodies react with it. This autoantibody is found in scleromyositis or the overlap syndrome of systemic sclerosis and polymyositis, the clinical diagnosis made by the physicians attending the patient. Even though anti–PM-Scl antibody can be found in patients with polymyositis . . . [Full Text of this Article]

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