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Correspondence
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Volume 346:211-212 January 17, 2002 Number 3
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More on Rotavirus Vaccination and Intussusception

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To the Editor: In the February 22 issue of the Journal, we reported a strong and temporal association between vaccination with rhesus–human reassortant rotavirus vaccine (RRV-TV) and intussusception, which we found by examining the rate of intussusception during predefined periods after vaccination.1 Excess cases of intussusception above the base-line rate were evident when the number of occurrences was averaged over the maximal available follow-up period, a mean of 3.7 months per infant (adjusted odds ratio for intussusception, 2.2; 95 percent confidence interval, 1.5 to 3.3). During days 3 to 7 after dose 1, the adjusted odds ratio was 37.2 (95 . . . [Full Text of this Article]

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