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Correspondence
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Volume 346:455-456 February 7, 2002 Number 6
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Withholding Proven Treatment in Research

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To the Editor: In their editorial (Sept. 20 issue),1 Huston and Peterson discuss developments in the debate about withholding proven treatment in clinical research. Unfortunately, the editorialists, citing the transcript of a television report in which plaintiffs in a pending lawsuit described their allegations, do not accurately describe the clinical research on schizophrenia that was conducted at the University of California, Los Angeles (UCLA). In the UCLA study,2 which was conducted between 1982 and 1993, patients consented to discontinue medication only after clinical stabilization had been achieved, and they were monitored closely. Offering patients with stabilized illness a trial period . . . [Full Text of this Article]

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