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Previous Volume 346:536-538 February 14, 2002 Number 7 Next

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To the Editor: Dishy et al. (Oct. 4 issue)¹ report that polymorphisms of the ₂-adrenergic receptor influence agonist-promoted desensitization of ₂-adrenergic receptor–mediated vasodilatation. Desensitization can be an important homeostatic event but may also limit the therapeutic effectiveness of agonists (a response called tachyphylaxis). The authors indicate that their findings were unexpected, given results of in vitro studies in which my colleagues and I used polymorphic ₂-adrenergic receptors that were expressed in cells in either recombinant² or native³ form. However, the effect of polymorphisms in vivo is dependent on whether receptors are under static or dynamic regulation. The concept (Figure . . . [Full Text of this Article]

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