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Previous Volume 346:538-539 February 14, 2002 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Martin and colleagues (Oct. 4 issue)¹ report a case of type 1 diabetes mellitus in a patient with profound B-cell deficiency. It is now clear that B-cell–deficient nonobese diabetic (NOD) mice exhibit profound resistance to spontaneous autoimmune diabetes.^2,3,4 Indeed, several studies have indicated that the antigen-presenting role of B cells is crucial for the activation of diabetogenic T cells.³ Recently, detailed characterization of B-cell–deficient NOD mice⁵ showed that, despite their resistance to spontaneous autoimmune diabetes, these mice are susceptible to mild insulitis and, on treatment with cyclophosphamide, are susceptible to the development of diabetes.

These findings led . . . [Full Text of this Article]

References

This article has been cited by other articles:

• Hanifi-Moghaddam, P., Schloot, N. C., Kappler, S., Seissler, J., Kolb, H. (2003). An Association of Autoantibody Status and Serum Cytokine Levels in Type 1 Diabetes. Diabetes 52: 1137-1142 [Abstract] [Full Text]  
• Berzins, S. P., Venanzi, E. S., Benoist, C., Mathis, D. (2003). T-Cell Compartments of Prediabetic NOD Mice. Diabetes 52: 327-334 [Abstract] [Full Text]