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Previous Volume 346:628-629 February 21, 2002 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Mendonca et al. (Oct. 11 issue)¹ conclude that the finding of discordance in growth and genital development in monozygotic twins "convincingly" rules out a genetic cause of male pseudohermaphroditism. There are known genetic mechanisms that could account for the discordance. Fourteen cases of discordance in monozygotic twins have been reported in Beckwith–Wiedemann syndrome.^2,3 Alternatively, a nondisjunction or reduplication event at the time of the first cell division could result in uniparental disomy of a chromosome (i.e., both chromosomes are inherited from either the father or the mother). Maternal uniparental disomy of chromosome 7 has been associated with . . . [Full Text of this Article]

References

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• Philibert, P., Zenaty, D., Lin, L., Soskin, S., Audran, F., Leger, J., Achermann, J. C., Sultan, C. (2007). Mutational analysis of steroidogenic factor 1 (NR5a1) in 24 boys with bilateral anorchia: a French collaborative study. Hum Reprod 22: 3255-3261 [Abstract] [Full Text]