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Previous Volume 346:707-708 February 28, 2002 Number 9 Next

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To the Editor: Herndon et al. (Oct. 25 issue)¹ report that propranolol attenuates hypermetabolism and reverses muscle-protein catabolism in patients with severe burns. However, these conclusions must be critically examined, because the findings may be attributable to overfeeding. Patients in both groups received approximately 2000 kcal per day (57 and 70 kcal per kilogram of body weight in the control and propranolol groups, respectively). Both groups had a positive energy balance, with measured energy expenditures of 1670 and 1321 kcal per day, respectively, at two weeks, but the propranolol group had a daily caloric balance that was greater than that . . . [Full Text of this Article]

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