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A variety of hematologic cancers have served as examples of how to cure the disease by a step-by-step application of new treatments as they become available, but it must be admitted that during the past 10 years there have been no real breakthroughs in the fields of conventional chemotherapy, radiotherapy, or even marrow-ablative treatment followed by transplantation of stem cells. On average, half the patients eligible for the most effective treatment are cured, but the other half, with disease that is less responsive to treatment, still has a most unfavorable prognosis. Apparently, the limits of the possible have been reached
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