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Original Article
Brief Report
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Volume 347:731-736 September 5, 2002 Number 10
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A Patient with HIV-1 Superinfection
Stephanie Jost, B.Sc., Marie-Charlotte Bernard, M.D., Laurent Kaiser, M.D., Sabine Yerly, M.S., Bernard Hirschel, M.D., Assia Samri, Ph.D., Brigitte Autran, M.D., Li-Ean Goh, Pharm.D., and Luc Perrin, M.D.

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Commentary
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 by Goulder, P. J.R.

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The detection of an increasing number of circulating recombinant strains of human immunodeficiency virus type 1 (HIV-1) indicates that genetic recombination can occur in cells infected with two strains of HIV-1.1,2 Coinfection with two circulating strains of HIV-1 has been detected in a few subjects in communities where HIV-1 infection is endemic.3 Coinfection may result from exposure to a second virus either shortly after the initial infection or during the course of established HIV-1 infection; the latter circumstance is called superinfection.

Most viral infections induce lifelong immunity, but reinfection with respiratory viruses such as respiratory syncytial virus is common, most . . . [Full Text of this Article]

Case Report

Methods

Assays

Subtype-Specific Polymerase Chain Reaction

HIV-1 Proviral DNA PCR

Isolation and Growth of Subtypes AE and B in Vitro

Interferon-{gamma} CD8 Enzyme-Linked Immunospot Assay

Results

Discussion


Source Information

From the Division of Infectious Diseases, University of Geneva, Geneva (S.J., M.-C.B., L.K., S.Y., B.H., L.P.); the Laboratoire d'Immunologie Cellulaire, Hôpital Pitié Salpêtrière, Paris (A.S., B.A.); and Clinical Development Medical Affairs, GlaxoSmithKline, Greenford, United Kingdom (L.-E.G.).

Address reprint requests to Dr. Perrin at the Laboratory of Virology, Geneva University Hospital, 1211 Geneva 14, Switzerland, or at luc.perrin@hcuge.ch.


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