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Review Article
Medical Progress
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Volume 347:738-748 September 5, 2002 Number 10
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IgA Nephropathy
James V. Donadio, M.D., and Joseph P. Grande, M.D., Ph.D.

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IgA nephropathy is a relatively newly recognized disease, first described by Berger and Hinglais in 1968.1 It is now generally known to be the most common form of primary glomerulonephritis throughout the world.2,3,4

Primary IgA nephropathy is an immune-complex–mediated glomerulonephritis defined immunohistologically by the presence of glomerular IgA deposits accompanied by a variety of histopathologic lesions.5,6 Although primary IgA nephropathy receives the most attention, many other diseases are also associated with glomerular IgA deposits (Table 1). The most common of these is Schönlein–Henoch purpura. This condition may indeed be indistinguishable from primary IgA nephropathy and may represent a . . . [Full Text of this Article]

Demographic Features

Incidence

Causes and Genetic Factors

Pathogenesis

Pathology

Clinical Features

Outcome

Treatment

Angiotensin-Converting–Enzyme Inhibitors

Corticosteroids

n–3 Polyunsaturated Fatty Acids

Other Treatments

Renal Transplantation

Differential Diagnosis

Summary


Source Information

From the Division of Nephrology, Department of Medicine (J.V.D.), and the Department of Laboratory Medicine and Pathology (J.P.G.), Mayo Clinic and Mayo Foundation, Rochester, Minn.

Address reprint requests to Dr. Donadio at the Mayo Clinic, 200 First St. SW, Stabile 7-22, Rochester, MN 55905, or at donadio.james@mayo.edu.


Related Letters:

IgA Nephropathy
Heine G., Sester U., Kohler H., Wardle E. N., Sedlacek M., Donadio J. V., Grande J. P.
Extract | Full Text | PDF  
N Engl J Med 2003; 348:79-81, Jan 2, 2003. Correspondence

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