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Previous Volume 347:772 September 5, 2002 Number 10 Next

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Edited by Emilio A. Emini. 544 pp., illustrated. Princeton, N.J., Princeton University Press, 2002. $75. ISBN 0-691-00454-4.

This book addresses our knowledge about replication of the human immunodeficiency virus (HIV), with a particular emphasis on drugs and compounds that inhibit it. The last three chapters cover nonpharmaceutical prevention strategies, immunity to HIV infection, and the prospects for the development of a vaccine. Current treatment of HIV infection exemplifies the practical outcome of rational drug design. In the 19 years since virologists at the Institut Pasteur first isolated HIV, the detailed understanding of its molecular biology has led to successful drug regimens involving combinations of drugs that inhibit reverse transcription early in the infection cycle and inhibit protein . . . [Full Text of this Article]

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