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Editorial
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Volume 347:930-931 September 19, 2002 Number 12
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Eat Dirt — The Hygiene Hypothesis and Allergic Diseases

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 by Braun-Fahrländer, C.
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 by Bach, J.-F.
-PubMed Citation
There has been an epidemic of both autoimmune diseases (in which the immune response is dominated by type 1 helper T [Th1] cells, such as type 1 diabetes, Crohn's disease, and multiple sclerosis) and allergic diseases (in which the immune response is dominated by type 2 helper T [Th2] cells, such as asthma, allergic rhinitis, and atopic dermatitis), as documented in the article by Bach in this issue of the Journal.1 The occurrence of these diseases is higher in more affluent, Western, industrialized countries. One theory proposed to explain this increase in the prevalence of autoimmune and allergic diseases is . . . [Full Text of this Article]


Related Letters:

Endotoxin and Asthma
Maziak W., Perzanowski M. S., Platts-Mills T. A.E., Speiser D. E., Zippelius A., Braun-Fahrländer C., Lauener R. P., von Mutius E., Weiss S. T.
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N Engl J Med 2003; 348:171-174, Jan 9, 2003. Correspondence

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