There has been an epidemic of both autoimmune diseases (in whichthe immune response is dominated by type 1 helper T [Th1] cells,such as type 1 diabetes, Crohn's disease, and multiple sclerosis)and allergic diseases (in which the immune response is dominatedby type 2 helper T [Th2] cells, such as asthma, allergic rhinitis,and atopic dermatitis), as documented in the article by Bachin this issue of the Journal.1 The occurrence of these diseasesis higher in more affluent, Western, industrialized countries.One theory proposed to explain this increase in the prevalenceof autoimmune and allergic diseases is . . . [Full Text of this Article]
Related Letters:
Endotoxin and Asthma
Maziak W., Perzanowski M. S., Platts-Mills T. A.E., Speiser D. E., Zippelius A., Braun-Fahrländer C., Lauener R. P., von Mutius E., Weiss S. T.
Extract |
Full Text |
PDF
N Engl J Med 2003;
348:171-174, Jan 9, 2003.
Correspondence
This article has been cited by other articles:
Wexler, H. M.
(2007). Bacteroides: the Good, the Bad, and the Nitty-Gritty. Clin. Microbiol. Rev.
20: 593-621
[Abstract][Full Text]
Tirosh, A., Mandel, D., Mimouni, F. B., Zimlichman, E., Shochat, T., Kochba, I.
(2006). Autoimmune diseases in asthma.. ANN INTERN MED
144: 877-883
[Abstract][Full Text]
Yan, A. C.
(2004). Time to Tidy Up the Hygiene Hypothesis Regarding the Risk of Atopic Dermatitis. AAP Grand Rounds
12: 34-34
[Full Text]
Park, J.-H., Szponar, B., Larsson, L., Gold, D. R., Milton, D. K.
(2004). Characterization of Lipopolysaccharides Present in Settled House Dust. Appl. Environ. Microbiol.
70: 262-267
[Abstract][Full Text]
Lutton, J. D., Winston, R., Rodman, T. C.
(2004). Multiple Sclerosis: Etiological Mechanisms and Future Directions. Exp. Biol. Med.
229: 12-20
[Abstract][Full Text]
Kurtaran, H., Karadag, A., Catal, F., Avci, Z., Huang, J.-L.
(2003). A Reappraisal of Nasal Saline Solution Use in Chronic Sinusitis. Chest
124: 2036-2038
[Full Text]
Lundy, S. K., Berlin, A. A., Lukacs, N. W.
(2003). Interleukin-12-Independent Down-Modulation of Cockroach Antigen-Induced Asthma in Mice by Intranasal Exposure to Bacterial Lipopolysaccharide. Am. J. Pathol.
163: 1961-1968
[Abstract][Full Text]
Watanabe, J., Miyazaki, Y., Zimmerman, G. A., Albertine, K. H., McIntyre, T. M.
(2003). Endotoxin Contamination of Ovalbumin Suppresses Murine Immunologic Responses and Development of Airway Hyper-reactivity. J. Biol. Chem.
278: 42361-42368
[Abstract][Full Text]
Silverman, E. S., Drazen, J. M.
(2003). Immunostimulatory DNA for Asthma: Better than Eating Dirt. Am. J. Respir. Cell Mol. Bio.
28: 645-647
[Full Text]
Ente, G.
(2003). Exposure to Pets in Childhood and Risk of Atopic Disorders. JAMA
289: 842-842
[Full Text]
Maziak, W., Perzanowski, M. S., Platts-Mills, T. A.E., Speiser, D. E., Zippelius, A., Braun-Fahrlander, C., Lauener, R. P., von Mutius, E., Weiss, S. T.
(2003). Endotoxin and Asthma. NEJM
348: 171-174
[Full Text]
(2002). More Support for the "Hygiene Hypothesis" and Asthma. JWatch General
2002: 5-5
[Full Text]