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Previous Volume 347:936-938 September 19, 2002 Number 12 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Asthma is thought to result from complex interactions between genes and the environment. Although allergens and endotoxins appear to be environmental modifiers of asthma,^1,2 the genes involved have been harder to identify. However, progress is now being made. For example, Van Eerdewegh and colleagues conducted genetic-linkage analysis on 460 pairs of siblings from affected families in the United States and United Kingdom and identified a locus on the short arm of chromosome 20 that was linked to asthma and bronchial hyperresponsiveness.³ They assessed 135 polymorphisms of 23 genes in this region and identified the ADAM-33 gene as significantly associated with . . . [Full Text of this Article]

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