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Volume 347:966-967 September 26, 2002 Number 13 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Sepsis, a leading cause of death in the United States, is now viewed physiologically as a proinflammatory and procoagulant response to invading pathogens. There are three recognized stages in the hierarchy of the inflammatory response, with progressively increased risk of end-organ failure and death: sepsis, severe sepsis, and septic shock. Patients with infection plus two or more elements of the systemic inflammatory response syndrome meet the criteria for sepsis; those who also have end-organ failure are considered to have severe sepsis; and those who also have refractory hypotension are considered to be in septic shock (see Figure). Because the . . . [Full Text of this Article]

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