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Volume 347:1208-1209 October 10, 2002 Number 15
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Human Immunodeficiency Virus in Pregnancy

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by Watts, D. H.
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To the Editor: In her review of the management of human immunodeficiency virus (HIV) infection during pregnancy (June 13 issue),1 Watts recommends addressing coexisting herpes simplex virus (HSV) infection as one would for a nonpregnant patient. However, it may be rational to prescribe daily suppressive doses of acyclovir during the last trimester — certainly for those with a history of genital HSV disease, and perhaps empirically for all HIV-infected women, lest an inopportune outbreak of HSV during labor and delivery increase the risk of vertical transmission of HIV. HIV is expressed in high titers in herpetic ulcers — disproportionately more . . . [Full Text of this Article]



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