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Previous Volume 347:1364-1367 October 24, 2002 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The finding that infections with drug-resistant human immunodeficiency virus (HIV) are increasing in North America¹ underscores the need to develop inhibitors of HIV molecules other than reverse transcriptase and protease. Several groups have focused on HIV messenger RNAs (mRNAs) and the viral genome itself, which can be degraded by RNA interference.^2,3,4 RNA interference is a general mechanism for silencing the transcript of an active gene, mRNA. This process of post-transcriptional gene silencing is initiated by small interfering RNA (siRNA), a double-stranded form of RNA that contains 21 to 23 bp and is highly specific for the nucleotide sequence of its . . . [Full Text of this Article]

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RNA Interference
Rowley P. T., Kitabwalla M., Ruprecht R. M.
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N Engl J Med 2003; 348:564, Feb 6, 2003. Correspondence

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