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Previous Volume 347:1379-1381 October 24, 2002 Number 17 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Cummings et al. (May 23 issue)¹ report that, unlike diet-induced weight loss, weight reduction after gastric bypass is associated with markedly low levels of ghrelin. We would caution against concluding, as they do, that suppression of ghrelin is responsible for the weight-reducing effect of gastric bypass. First, the plasma ghrelin concentration is negatively correlated with the body-mass index (the weight in kilograms divided by the square of the height in meters).² In the study by Cummings et al., the mean preoperative body-mass index of surgical patients was 68, whereas the diet-treated obese controls had an initial body-mass . . . [Full Text of this Article]

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