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Previous Volume 347:1445-1447 October 31, 2002 Number 18 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Multiple sclerosis is the most common nontraumatic disorder of the central nervous system in young adults. Twenty years after the onset of disease, 90 percent of cases will have entered a progressive phase.

Strong circumstantial evidence implicates an autoimmune mechanism in multiple sclerosis. The results of family studies illustrate the importance of genes in the familial aggregation of the disease. However, most monozygotic twins are discordant for the disease, and the markedly reduced risk of susceptible populations in subtropical regions demonstrates the substantial role of environmental effects.

As in many putatively autoimmune diseases, susceptibility to multiple sclerosis is governed in . . . [Full Text of this Article]

Effector Candidates

Candidate Susceptibility Genes

The Future

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