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Correspondence
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Volume 347:1533 November 7, 2002 Number 19
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Hypocapnia

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 by Laffey, J. G.
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To the Editor: The otherwise excellent review of hypocapnia by Laffey and Kavanagh (July 4 issue)1 was somewhat diminished by an oversimplified discussion of the effects of hypocapnia on the cerebral circulation. We would like to add two points. First, hypocapnia reduces cerebral blood flow but expands the plateau region of the cerebral autoregulatory curve, thereby improving cerebral autoregulation, the inherent ability of the cerebrovasculature to keep cerebral blood flow constant for a wide range of perfusion pressures.2 As the authors rightly point out, increasing cerebral blood flow by whatever means may not always be in a patient's best interest, . . . [Full Text of this Article]




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