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Volume 347:1546-1547 November 14, 2002 Number 20 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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An early and essential event in the evolution of cancer is loss of the normal control mechanisms responsible for the orderly progression of cells through the cell cycle, with consequent reduced fidelity of DNA replication and inappropriate cell division. Cyclins are the regulatory partners of the cyclin-dependent kinases (CDKs), which form the molecular control mechanisms responsible for cell-cycle progression.

An advanced understanding of cell-cycle control has evolved over the past decade, since it became apparent that the underlying machinery of this fundamental biologic process was conserved during evolution. Indeed, the importance of these control mechanisms and their relevance to human . . . [Full Text of this Article]

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• Garcia, H. H., Brar, G. A., Nguyen, D. H. H., Bjeldanes, L. F., Firestone, G. L. (2005). Indole-3-Carbinol (I3C) Inhibits Cyclin-dependent Kinase-2 Function in Human Breast Cancer Cells by Regulating the Size Distribution, Associated Cyclin E Forms, and Subcellular Localization of the CDK2 Protein Complex. J. Biol. Chem. 280: 8756-8764 [Abstract] [Full Text]