An early and essential event in the evolution of cancer is lossof the normal control mechanisms responsible for the orderlyprogression of cells through the cell cycle, with consequentreduced fidelity of DNA replication and inappropriate cell division.Cyclins are the regulatory partners of the cyclin-dependentkinases (CDKs), which form the molecular control mechanismsresponsible for cell-cycle progression.
An advanced understanding of cell-cycle control has evolvedover the past decade, since it became apparent that the underlyingmachinery of this fundamental biologic process was conservedduring evolution. Indeed, the importance of these control mechanismsand their relevance to human . . . [Full Text of this Article]
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