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Correspondence
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Volume 347:1623-1624 November 14, 2002 Number 20
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Lansoprazole for the Prevention of Recurrences of Ulcer Complications from Long-Term Low-Dose Aspirin

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by Lai, K. C.
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To the Editor: Lai et al. (June 27 issue)1 report that lansoprazole after the eradication of Helicobacter pylori was significantly better than eradication alone in decreasing the risk of recurrence of ulcer complications in patients with long-term low-dose aspirin use. In their study, 61 patients were randomly assigned to receive placebo after therapy to eradicate H. pylori, and 9 of these patients had further ulcer complications. It appears, however, that four of the nine patients were reinfected with H. pylori, and an additional two patients took other nonsteroidal antiinflammatory drugs. If these 6 patients are excluded from the analysis, is . . . [Full Text of this Article]



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