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Correspondence
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Volume 347:1624-1625 November 14, 2002 Number 20
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Varicella Vaccine in Recipients of Hematopoietic-Cell Transplants

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 by Hata, A.
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To the Editor: Hata et al. (July 4 issue)1 report that inactivated varicella vaccine given before and after hematopoietic-cell transplantation reduces the risk of zoster. The primary end point of their study was the development of zoster within 12 months after transplantation. We believe, however, that the follow-up is too short to support a definite conclusion concerning the effect of vaccination. Offidani et al.2 reported that the actuarial probability of varicella–zoster virus infection in 164 recipients of autologous hematopoietic-cell transplants was 10 percent at one year, 17 percent at two years, and 24 percent at three years. In the study . . . [Full Text of this Article]


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