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Correction to Antin, N Engl J Med 347(1):36-42 July 4, 2002.

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Volume 347:1625-1626 November 14, 2002 Number 20
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Long-Term Care after Hematopoietic-Cell Transplantation in Adults

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 by Antin, J. H.
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 by Antin, J. H.
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To the Editor: In his Clinical Practice article (July 4 issue),1 Antin does not discuss an important cause of late death after hematopoietic stem-cell transplantation: invasive fungal infection. Several centers have reported that such infections (such as invasive aspergillosis) occur in up to 15 percent of recipients of allogeneic hematopoietic stem-cell transplants and are most commonly encountered in the late phase.2 Chronic graft-versus-host disease and therapy with corticosteroids are important risk factors for these infections.2 With increasing treatment options that include azole antifungal agents, aggressive diagnostic workup and treatment should be pursued; prophylaxis with azoles in patients at highest risk . . . [Full Text of this Article]


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