The definition of transient ischemic attack (TIA) and the assumptionsunderlying the definition have been out of date for some timeand are no longer consistent with current concepts of brainischemia. The classic definition of TIA is a sudden, focal neurologicdeficit that lasts for less than 24 hours, is presumed to beof vascular origin, and is confined to an area of the brainor eye perfused by a specific artery. Typical symptoms includehemiparesis, hemiparesthesia, dysarthria, dysphasia, diplopia,circumoral numbness, imbalance, and monocular blindness. TIAsare often referred to as ministrokes, warning strokes, or transientstrokes because . . . [Full Text of this Article]
Historical Considerations
Recent Data on the Duration of Symptoms
Additional Reasons for Changing the Definition
New Concepts of the Pathophysiology of Cerebral Ischemia
Renaming or Redefining TIA
Proposed New Definition
Conclusions
Related Letters:
Transient Ischemic Attack Proposed New Definition
Brown M. M., Rudd A., McGovern R., Ballotta E., Toniato A., Baracchini C., Bernstein R. A., Alberts M. J., Saver J. L., Albers G. W., Easton J. D., the TIA Working Group
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N Engl J Med 2003;
348:1607-1609, Apr 17, 2003.
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[Full Text]