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Previous Volume 347:1770-1782 November 28, 2002 Number 22 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Typhoid fever is a systemic infection with the bacterium Salmonella enterica serotype typhi. This highly adapted, human-specific pathogen has evolved remarkable mechanisms for persistence in its host that help to ensure its survival and transmission. Typhoid fever was an important cause of illness and death in the overcrowded and unsanitary urban conditions of the United States and Europe in the 19th century.¹ The provision of clean water and good sewage systems led to a dramatic decrease in the incidence of typhoid in these regions. Today most of the burden of the disease occurs in the developing world, where sanitary conditions . . . [Full Text of this Article]

The Bacterium

The Genome

Pathogenesis

Antimicrobial Resistance

Clinical Features

Management

Diagnosis

Treatment

Severe Typhoid

Control of Typhoid

The Future

Source Information

From the Centre for Tropical Medicine, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom (C.M.P., N.J.W., J.J.F.); the Centre for Molecular Microbiology and Infection, Department of Biological Sciences, Imperial College of Science, Technology and Medicine, London (G.D.); the Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam (T.T.H.); the Wellcome Trust–Mahidol University–Oxford Tropical Medicine Research Programme, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand (N.J.W.); and the University of Oxford Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam (J.J.F.).

Address reprint requests to Dr. Farrar at the University of Oxford Clinical Research Unit, Hospital for Tropical Diseases, 190 Ben Ham Tu, Quan 5, Ho Chi Minh City, Vietnam, or at jeremyjf@hcm.vnn.vn.

Related Letters:

Typhoid Fever
van Doorn K. J., Pierard D., Verbeelen D., Basnyat B., Zaidi A. K.M., Hasan R., Bhutta Z. A., Parry C. M., Hien T. T., White N. J., Farrar J. J.
Extract | Full Text | PDF  
N Engl J Med 2003; 348:1182-1184, Mar 20, 2003. Correspondence

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