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Previous Volume 347:1860-1866 December 5, 2002 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the authors' clinical recommendations.

Patient 1, a 44-year-old man who recently immigrated from Peru, is found to have induration of 16 mm in diameter on a tuberculin skin test. He received bacille Calmette–Guérin (BCG) vaccine as an infant and is asymptomatic. Chest radiography shows fibronodular opacities in the upper lobe. Patient 2, a 27-year-old schoolteacher who was born in the United States, has induration of 17 . . . [Full Text of this Article]

The Clinical Problem

Strategies and Evidence

Identifying Latent Tuberculosis Infection

            Who Should Be Tested?

            The Tuberculin Skin Test

            Whole-Blood Interferon-Gamma Assay

            Ruling out Active Tuberculosis

Treatment Regimens for Latent Tuberculosis Infection

            Isoniazid

            Rifampin

            Rifampin and Pyrazinamide

Areas of Uncertainty

Guidelines

Determining Whom to Treat

Treatment Regimens

Conclusions and Recommendations

Source Information

From the Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, and the Department of Medicine, University of California, San Francisco — both in San Francisco.

Address reprint requests to Dr. Jasmer at the Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, Rm. 5K-1, 1001 Potrero Ave., San Francisco, CA 94110, or at rjasmer@itsa.ucsf.edu.

Related Letters:

Treatment of Latent Tuberculosis Infection
Barton L. L., Lepage P., De Rosa F. G., Craven D. E., Meyer B. C., Jasmer R. M., Nahid P., Hopewell P. C.
Extract | Full Text | PDF  
N Engl J Med 2003; 348:1292-1293, Mar 27, 2003. Correspondence

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