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Correspondence
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Volume 347:1895-1896 December 5, 2002 Number 23
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Cardiomyopathy with Mitochondrial Damage Associated with Nucleoside Reverse-Transcriptase Inhibitors

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To the Editor: In July 2000, a 58-year-old man infected with the human immunodeficiency virus (HIV) began treatment with highly active antiretroviral therapy, which initially consisted of zidovudine, lamivudine, and ritonavir-boosted indinavir. After three months, a buffalo hump, anemia, and proximal muscle weakness developed, and the regimen was therefore switched to stavudine, lamivudine, and nevirapine. Because of pain in his legs, stavudine was replaced with abacavir three months later.

In February 2001, the patient was admitted to our hospital because of progressive exertional dyspnea and peripheral edema. At that time, his CD4 count had risen to 160 per cubic millimeter . . . [Full Text of this Article]




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