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Genetics, until recently the domain of molecular biologists, mathematicians, anthropologists, forensic scientists, pediatricians, and families concerned about rare and esoteric diseases, today captures the imagination of a wide spectrum of basic scientists and clinicians. The principal reasons for this remarkable shift are the explosion of new knowledge about the genetic basis of numerous diseases, the rapid progress in sequencing and assembling the human and mouse genomes, and the insights gained from transgenic and gene-knockout animals. The clarity that modern molecular genetics has brought to our understanding of the nature and causation of previously obscure syndromes is stunning. The mysteries of
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