The symptoms of anxiety disorders frequently begin in childhood.However, the full importance of childhood shyness and inhibitedbehavior as predictors of dysfunction during adulthood and asindicators of the need for treatment in childhood is still unclear.There is as yet no pathophysiologic model that relates earlychildhood symptoms, some of which may seem like normal aspectsof growing up, to more severe illness in adults. Gross and colleaguesat Columbia University1 recently reported experiments in geneticallyengineered mice that elucidate an aspect of the genetic controlof behavior that may have relevance to clinical work with shy,behaviorally . . . [Full Text of this Article]