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Clinical Implications of Basic Research
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Volume 347:213-215 July 18, 2002 Number 3
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Long-Term Effects of Early Genetic Influences on Behavior

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The symptoms of anxiety disorders frequently begin in childhood. However, the full importance of childhood shyness and inhibited behavior as predictors of dysfunction during adulthood and as indicators of the need for treatment in childhood is still unclear. There is as yet no pathophysiologic model that relates early childhood symptoms, some of which may seem like normal aspects of growing up, to more severe illness in adults. Gross and colleagues at Columbia University1 recently reported experiments in genetically engineered mice that elucidate an aspect of the genetic control of behavior that may have relevance to clinical work with shy, behaviorally . . . [Full Text of this Article]


Related Letters:

Anxiety and Genetically Engineered Mice
Diller L. H., Carey W. B., Freedman R.
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N Engl J Med 2002; 347:1626, Nov 14, 2002. Correspondence

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