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Previous Volume 347:216-218 July 18, 2002 Number 3 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Côté et al. (March 14 issue)¹ propose that the mitochondrial DNA level in patients infected with the human immunodeficiency virus (HIV) be measured as a marker of nucleoside toxicity. The fact that nucleoside analogues can cause a depletion of mitochondrial DNA is well established.² In HIV-infected patients, an association between drug toxicity and mitochondrial DNA depletion has been demonstrated in skeletal muscle and liver tissue.³ Côté et al. report that in eight HIV-positive patients toxic effects of nucleoside analogues were late events and suggest that the decline in the mitochondrial DNA level preceded symptomatic hyperlactatemia. The authors . . . [Full Text of this Article]

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