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Previous Volume 347:362-364 August 1, 2002 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Although some mechanisms by which acute pain evolves into a chronic syndrome are known, many others, including changes in the brain stem, thalamus, and cerebral cortex, are not understood. Moreover, even though chronic neuropathic and inflammatory pain can be relieved to some extent with opiate compounds, these syndromes are still poorly understood. The treatment options for pain with a central cause are even more bleak. Now, however, the revolution in genomic engineering has opened up new possibilities for studying the mechanisms of acute and chronic pain and designing novel and more selective drugs.

Prodynorphin is the precursor of dynorphin, an . . . [Full Text of this Article]

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