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Volume 347:370-371 August 1, 2002 Number 5
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Fluconazole for the Treatment of Cutaneous Leishmaniasis

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 by Alrajhi, A. A.
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To the Editor: Alrajhi et al. (March 21 issue)1 report on the efficacy of systemic fluconazole for Old World cutaneous leishmaniasis caused by Leishmania major. Although this therapy was more efficacious than placebo, the rationale for the study is questionable. Because of potential side effects and high costs, it is unlikely that any systemic therapy will ever become the first-choice therapy for uncomplicated Old World cutaneous leishmaniasis, which is a self-limited skin disease that is usually amenable to topical treatments. Moreover, the cost of six weeks of treatment with fluconazole at a dose of 200 mg per day is . . . [Full Text of this Article]


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