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Previous Volume 347:373-374 August 1, 2002 Number 5 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Eiro et al. (Jan. 10 issue)¹ report that therapy with a proton-pump inhibitor may be useful in correcting the metabolic abnormalities in patients with eating disorders involving self-induced vomiting. Although the loss of hydrogen ions initiates vomiting-induced metabolic alkalosis, the primary reason that the alkalosis persists is the loss of sodium chloride. The resultant reduction in intravascular volume leads to an increase in aldosterone secretion, which increases sodium bicarbonate reabsorption by the distal nephron and results in maintenance of the metabolic alkalosis. Proton-pump inhibitors do not affect this primary causal factor.

As a corollary, the efficacy of . . . [Full Text of this Article]

Related Letters:

Use of a Proton-Pump Inhibitor for Metabolic Disturbances Associated with Anorexia Nervosa
Eiro M., Katoh T., Watanabe T.
Extract | Full Text | PDF  
N Engl J Med 2002; 346:140, Jan 10, 2002. Correspondence

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