In the decades since the major forms of idiopathic inflammatorybowel disease were defined on the basis of clinical manifestations,investigators have been challenged to identify the fundamentalpathophysiologic processes underlying these enigmatic disorders,and clinicians have struggled to provide effective therapy forthe often dismaying clinical manifestations. Clinical experiencehas led to the generally accepted notion that Crohn's diseaseand ulcerative colitis are distinct, if not discrete, entities.However, whether these are fundamentally different diseasesor part of a mechanistic continuum remains an unanswered question,with both conceptual and practical management implications.
From the Gastrointestinal Unit and the Center for the Study of Inflammatory Bowel Disease, Massachusetts General Hospital and Harvard Medical School, Boston.
Related Letters:
Inflammatory Bowel Disease
García de Tena J., Espinosa L. M., Alvarez-Mon M., Famularo G., Trinchieri V., De Simone C., Marchetti F., Martelossi S., Ventura A., Mohammed F., Podolsky D. K.
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N Engl J Med 2002;
347:1982-1984, Dec 12, 2002.
Correspondence
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