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Previous Volume 347:448-449 August 8, 2002 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Johnson et al. (March 21 issue)¹ address the mechanism of salt-sensitive hypertension but omit the most perplexing step: how sodium retention increases blood pressure. Figure 3 of their article shows an arrow from sodium retention to increased blood pressure but offers no hint as to how the former leads to the latter.

This step is perplexing because induced sodium retention (e.g., by intravenous infusion of saline or blood) does not immediately raise blood pressure; increased pressure occurs only if sodium retention is sustained, suggesting an indirect mechanism. Proposed mechanisms have included increased cardiac output, leading to a . . . [Full Text of this Article]

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