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Previous Volume 347:609-612 August 22, 2002 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Advances in the field of mitochondrial genetics have challenged the general principles of molecular biology on several occasions. The universality of the genetic code that relates triplet-nucleotide sequences in DNA to specific amino acids in proteins was overturned by the discovery that the translation of mitochondrial proteins involves different coding rules.¹ Studies of mitochondria led to the surprising discoveries of autocatalytic RNA (RNA with enzymatic activity in the absence of proteins), RNA editing (post-transcriptional modification of the nucleotide sequence in messenger RNA [mRNA]), and trans-splicing (the joining of two separate primary RNA transcripts to form a single mRNA molecule).^2,3,4 In . . . [Full Text of this Article]

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