FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 347:614-615 August 22, 2002 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article by Huovinen, P. Related Article by Martin, J. M. PubMed Citation

To the Editor: Martin et al. (April 18 issue)¹ identified the emergence of a clone of macrolide-resistant group A streptococci among schoolchildren in Pittsburgh. We are concerned that, on the basis of this finding, physicians will unnecessarily choose even broader-spectrum antimicrobial agents for the treatment of pharyngitis caused by group A streptococci.

Our analysis of data collected in the National Ambulatory Medical Care Survey from 1989 to 1999 showed a significant increase in the use by primary care physicians of extended-spectrum macrolides (mostly clarithromycin and azithromycin) for adults with sore throat.² This increase probably provides the selective pressure necessary for . . . [Full Text of this Article]

This article has been cited by other articles:

• Block, S. L. (2006). Comparative Tolerability, Safety and Efficacy of Tablet Formulations of Twice-Daily Clarithromycin 250 mg versus Once-Daily Extended-Release Clarithromycin 500 mg in Pediatric and Adolescent Patients. CLIN PEDIATR 45: 641-648 [Abstract]  
• Hasenbein, M. E., Warner, J. E., Lambert, K. G., Cole, S. E., Onderdonk, A. B., McAdam, A. J. (2004). Detection of Multiple Macrolide- and Lincosamide-Resistant Strains of Streptococcus pyogenes from Patients in the Boston Area. J. Clin. Microbiol. 42: 1559-1563 [Abstract] [Full Text]  
• Katz, K. C., McGeer, A. J., Duncan, C. L., Ashi-Sulaiman, A., Willey, B. M., Sarabia, A., McCann, J., Pong-Porter, S., Rzayev, Y., de Azavedo, J. S., Low, D. E. (2003). Emergence of Macrolide Resistance in Throat Culture Isolates of Group A Streptococci in Ontario, Canada, in 2001. Antimicrob. Agents Chemother. 47: 2370-2372 [Abstract] [Full Text]