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Correspondence
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Volume 347:689-690 August 29, 2002 Number 9
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Responses to Smallpox Vaccine

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by Frey, S. E.
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by Frey, S. E.
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To the Editor: I am alarmed by the high rate of vaccinia-vaccine–associated morbidity (>30 percent) in the study by Frey et al. (April 25 issue).1 In their study, there were three deviations from prior standard procedures for vaccinia vaccination2,3,4,5 that may account for the unusually high rate of morbidity as compared with the rate at our clinic.6 First, their use of 15 scratches (part of the investigational-new-drug [IND] protocol for the vaccine) instead of the previously recommended 5 scratches for persons without prior vaccination results in a higher inoculum, which was previously reserved for persons with a prior vaccination.

Second, . . . [Full Text of this Article]


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