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Previous Volume 347:692 August 29, 2002 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Boylston (April 25 issue)¹ reminds us that clinical trials have been around a long time and that they are available to all, and he cites William Watson's contribution to the understanding of smallpox in 1767 as perhaps the first. But I offer James Lind's A Treatise of the Scurvy,² published in 1753, as an even earlier report of a clinical trial. It was simple and controlled and was not burdened by P values, review boards, or other impediments of modern science. Lind's two oranges and one lemon saved lives on his ship and soon saved lives the . . . [Full Text of this Article]

Related Letters:

Ancient Clinical Trials
Lewis E. J., Lepreau F. J.
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N Engl J Med 2003; 348:83-84, Jan 2, 2003. Correspondence

This article has been cited by other articles:

• Lewis, E. J., Lepreau, F. J. (2003). Ancient Clinical Trials. NEJM 348: 83-84 [Full Text]