FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 347:696-697 August 29, 2002 Number 9 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited Related Article PubMed Citation

To the Editor: We disagree strongly with the conclusions of Cothren et al. (April 4 issue)¹ about the benefits of the polymerized hemoglobin-based oxygen carrier PolyHeme in critically ill patients with anemia who refuse transfusions. Hemoglobin-based oxygen carriers are administered in such patients to increase oxygen delivery to the tissues, in order to maintain or restore oxygen uptake. Yet no data on tissue oxygen balance before and after the administration of the product are presented. Such products may not be associated with increased oxygen delivery when they cause vasoconstriction in the peripheral circulation and decrease cardiac output.^2,3 Finally, in order . . . [Full Text of this Article]

Related Letters:

Blood Substitute and Erythropoietin Therapy in a Severely Injured Jehovah's Witness
Cothren C., Moore E. E., Offner P. J., Haenel J. B., Johnson J. L.
Extract | Full Text | PDF  
N Engl J Med 2002; 346:1097-1098, Apr 4, 2002. Correspondence

HOME  |  SUBSCRIBE  |  SEARCH  |  CURRENT ISSUE  |  PAST ISSUES  |  COLLECTIONS  |  PRIVACY  |  TERMS OF USE  |  HELP  |  beta.nejm.org Comments and questions? Please contact us. The New England Journal of Medicine is owned, published, and copyrighted © 2009 Massachusetts Medical Society. All rights reserved.