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Previous Volume 348:68-72 January 2, 2003 Number 1 Next

₄ Integrins as Therapeutic Targets in Autoimmune Disease

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In this issue of the Journal, two groups of investigators report on clinical trials of natalizumab, a recombinant monoclonal antibody against ₄ integrins, for the treatment of multiple sclerosis¹ and Crohn's disease.² Miller et al. report that a group of patients with multiple sclerosis who received monthly injections of natalizumab had significantly fewer new inflammatory central nervous system lesions than the placebo group (a reduction of approximately 90 percent) and had approximately half as many clinical relapses.¹ Ghosh et al. report that patients with Crohn's disease also had an improved response to natalizumab,² with response and remission rates that were approximately . . . [Full Text of this Article]

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From the Center for Blood Research and Department of Pathology, Harvard Medical School, Boston (U.H.A.); and the Max Planck Institute for Vascular Biology, Münster, Germany (B.E.).

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