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The number of methadone-associated deaths in England and Wales rose from 371 in 1993 to 675 in 1997, when it was the most common cause of death associated with drug misuse.2 Nonfatal overdosing is common: in the past 21 months, there have been 51 cases of methadone overdose treated in our hospital alone, and several have required intensive care. The first two weeks of treatment are
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