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Previous Volume 348:919-932 March 6, 2003 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The annual incidence of colorectal cancer in the United States is approximately 148,300 (affecting 72,600 males and 75,700 females), with 56,600 deaths (in 27,800 males and 28,800 females).¹ The lifetime risk of colorectal cancer in the general population is about 5 to 6 percent.¹ Patients with a familial risk — those who have two or more first- or second-degree relatives (or both) with colorectal cancer — make up approximately 20 percent of all patients with colorectal cancer, whereas approximately 5 to 10 percent of the total annual burden of colorectal cancer is mendelian in nature — that is, it is . . . [Full Text of this Article]

Overall Clinical Approach

Diagnostic Clues

Familial Adenomatous Polyposis

Clinical and Molecular Features

Genetic Testing

Chemoprevention

Hereditary Nonpolyposis Colorectal Cancer

Clinical Features

Pathological Features

Accelerated Carcinogenesis

Features of Pedigrees

Incidence and Molecular Screening

Genes and Germ-Line Mutations

Assessing the Pathogenicity of Mutations

Sources of Underdiagnosis

Surveillance for Cancer

Efficacy of Surveillance

Somatic Mutations and the Progression to Cancer

Role of Epigenetics

Hamartomatous Polyposis Syndromes

Prospects for Prevention and Treatment

Source Information

From the Department of Preventive Medicine and Public Health, Creighton University School of Medicine, Omaha, Nebr. (H.T.L.); and the Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus (A.C.).

Address reprint requests to Dr. Lynch at the Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, or at htlynch@creighton.edu.

Related Letters:

Genetics of Colorectal Cancer
Chan W. M., Pang C. P., Lam D. S.C., Gripp K. W.
Extract | Full Text | PDF  
N Engl J Med 2003; 348:2361-2362, Jun 5, 2003. Correspondence

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