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Previous Volume 348:942-945 March 6, 2003 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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In a 1953 editorial entitled "The Need for an Inhibitor of Gonadotropin," Lawson Wilkins noted that a "method of suppressing the secretion of pituitary gonadotropins . . . might lead to the prevention or control of sexual precocity."¹ Almost 30 years later, Crowley and colleagues reported successful suppression of early puberty in a two-year-old girl with the use of a long-acting analogue of a luteinizing hormone–releasing hormone (LHRH) agonist.² In the intervening years, the nature of the hypothalamic–pituitary–gonadal axis was elucidated, LHRH was isolated, and maturational changes in the reproductive axis were characterized (Figure 1).

View larger version (58K): [in this window] [in a new window]   Figure 1. The Hypothalamic–Pituitary–Gonadal Axis. . . . [Full Text of this Article]

 

Source Information

From Duke University Medical Center, Durham, N.C.

Related Letters:

Is Luteinizing Hormone–Releasing Hormone Agonist Justified in Short Adolescents?
Taback S. P., Sellers E. A.C., Dean H. J., Lee M. M.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:192-193, Jul 10, 2003. Correspondence

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