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Case Records of the Massachusetts General Hospital
Weekly Clinicopathological Exercises
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Volume 348:1033-1044 March 13, 2003 Number 11
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Case 8-2003 — A 35-Year-Old Man with Early Dysfunction of a Second Renal Transplant
Mohamed H. Sayegh, M.D., and Robert B. Colvin, M.D.

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Presentation of Case

A 35-year-old man with end-stage renal disease and a history of failed renal transplantation was admitted to the hospital for another transplantation.

When the patient was 10 years old, diabetes mellitus type 1 developed, resulting in diabetic retinopathy, neuropathy, vasculopathy, hypertension, and hyperlipidemia. He underwent repeated procedures for a detached retina and was legally blind. Nine years before admission, renal failure occurred, and hemodialysis was begun. One year later, a right-sided nephrectomy and transplantation of a cadaveric kidney into the right iliac fossa were performed. Four years before admission, the patient's base-line creatinine concentration began rising from his usual level . . . [Full Text of this Article]

Differential Diagnosis

Renal-Allograft Rejection

Sensitization of Allograft Recipients

Clinical Diagnosis

Dr. Mohamed H. Sayegh's Diagnosis

Pathological Discussion

Anatomical Diagnosis


Source Information

From the Renal Division, Department of Medicine, Brigham and Women's Hospital (M.H.S.), the Department of Pathology, Massachusetts General Hospital (R.B.C.), and Harvard Medical School (M.H.S., R.B.C.) — all in Boston.


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