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Previous Volume 348:1059-1061 March 13, 2003 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: In the analysis by Ridker et al. (Nov. 14 issue),¹ several methodologic issues merit attention before claims of superiority for C-reactive protein in the prediction of cardiovascular risk can be substantiated. First, the authors did not adjust for body-mass index, which, given its strong correlation with C-reactive protein, is a major potential confounder of the relation between C-reactive protein and cardiovascular outcomes. Second, because high levels of low-density lipoprotein (LDL) cholesterol were undoubtedly treated during follow-up, the relation between LDL cholesterol and cardiovascular events was attenuated; similar treatment of high levels of C-reactive protein did not occur.

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